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During the subsequent OS, a Ca 2+ -dependent NADPH oxidase, known as NOX5 which is found in midpiece and acrosome of human sperm, is the major producer of reactive oxygen species [129] and also leads to DNA fragmentation of sperm

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Standard recommendations already favor GLP-1 receptor agonists for T2DM patients with prior atherosclerotic cardiovascular disease and SGLT-2 inhibitors for those with chronic kidney disease or heart failure

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